Chromatin interaction is the basis of eukaryotic genome assembly and plays an important role in regulating cell-specific expression of eukaryotic genes. The formation of chromatin interactions is associated with specific proteins. It has been suggested that CTCF and adhesion proteins are associated with chromatin interactions, but it is still unclear whether other proteins are involved in chromatin interactions. In this paper, we integrated Hi-C and ChIP-seq data to mine transcription factors related to chromatin interaction in both GM12878 and K562 cell lines, and performed the functional analysis of discovered transcription factors. We found that RUNX3, SPI1 and other transcription factors may also be involved in chromatin interaction in chromatin sites where interaction occurs frequently. In addition, using the data mining method of FP-growth, we found that multiple transcription factors may cooperate to participate in chromatin interaction. Our findings will provide prior knowledge for the development of chromatin interaction experiments.