School of Physics and Optoelectronic Engineering, Foshan University, Foshan 528000, China
This work is supported by grants from The National Natural Science Foundation of China(61605026, 11474053, 61471123, 61771139, 81601534, 61705036), Natural Science Foundation of Guangdong Province(2015A030313639, 2017A030313386) and the College Students Innovation and Entrensurship Training Program of Guangdong Province (XJ2018039).
We propose a high-dynamic optical angiography(HDOA) method to obtain blood flow images of a small biological specimen in vivo. High dynamic range exposure time is set to achieve high-dynamic integrated time modulation, which involves dynamic integrated effect and absorption effect. With this method, each-level vessels can be imaged with similar clarity. Moreover, the vessels in locations with different thickness and absorption coefficient can be reconstructed in the same image. Experiments on phantom and in vivo Gold Pristella Tetra were performed to demonstrate that HDOA can achieve each-level vessels imaging based on dynamic integrated effect and absorption effect.
ZENG Ya-Guang, LUO Jia-Xiong, HAN Ding-An, XIONG Hong-Lian, WANG Xue-Hua, ZHONG Jun-Ping, WANG Ming-Yi. High-Dynamic Optical Angiography[J]. Progress in Biochemistry and Biophysics,2019,46(6):612-619
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