Medical School, Kunming University of Science and Technology, Kunming 650500, China
The National Natural Science Foundation of China
Oncolytic viruses (OVs) are a type of natural or engineered viruses that preferentially target cancer cells. The engineered OVs can not only target cancer cells, but also regulate the tumor microenvironment which will have some effect on the therapeutic efficacy consequently. Oncolytic viruses are emerging as a system therapeutic strategies by modulating the expression of tumor antigens, immunosuppressive state, tumor-associated fibroblasts and angiogenesis in the tumor microenvironment. Moreover, the combination of OVs and immune checkpoint inhibitor can achieve very good synergistic and complementary effects. This paper summarized the progress of OVs on tumor microenvironment and combination therapy with immune checkpoint inhibitor.
TANG Lei, lipingcui, lirunfang, zhangjihong, songbin, duanwenfang, ZHANG Ji-Hong, yangfan. Advances on the regulation of tumor microenvironment and combination therapy by oncolytic viruses[J]. Progress in Biochemistry and Biophysics,2020,47(5):399-406
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