Osaka Institute of Medical Engineering, Ma’anshan University, Ma’anshan, 243100, China
The balance of cartilage and bone cells (osteoblasts and osteocytes) plays a crucial role in cartilage homeostasis and bone remodeling. This review focuses on the TGF-β canonical signaling pathway, highlights its influence on cartilage homeostasis and bone remodeling and presents different inhibitor and clinical applications in bone diseases. This review aims at providing new ideas and directions for the prevention and treatment of bone diseases.
WANG Li, XIE Yu-Long, ZHOU Feng. TGF-β Signaling on Balancing Osteoblast, Osteoclast and Chondrocyte[J]. Progress in Biochemistry and Biophysics,2022,49(4):725-736
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