The Establishment of Test Platforms for Terahertz Stimulation of Auditory Nerve
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1)Innovation Laboratory of Terahertz Biophysics, National Innovation Institute of Defense Technology, Beijing 100071, China;2)Astronaut Center of China, Beijing 100094, China

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    Abstract:

    Objective In recent years, neuromodulation techniques for brain function regulation have developed vigorously, and many methods have been popularized and applied in clinical practice, mainly including electrode deep brain stimulation, transcranial magnetic stimulation, photogenetic technology, ultrasonic deep brain stimulation, etc. However, these regulatory techniques have some problems, such as poor flexibility of stimulating target change, insufficient spatial resolution, and need to inject virus transfection. Compared with these techniques, terahertz (THz) wave regulation can intervene neural activity with higher spatial and temporal resolution without introducing foreign genes. Laser nerve stimulation is a specifically targeted stimulation method, which can control the excitation or inhibition of nerve by adjusting different laser parameters (laser wavelength, pulse energy, etc.). However, due to the lack of experimental means and platforms in this research direction, few relevant studies have been carried out.Methods To sum up, this paper sets up different testing platforms for related researches at molecular, cellular and somatic levels, starting from auditory nerve.Results The experimental results show that these systems have good coupling and targeting properties in time and space, and the measured signals are less disturbed by noise.Conclusion These systems can effectively test the response to terahertz stimulation and precisely control the timing and location of the stimulus.

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TAN Xiao-Xuan, YANG Xiao, CHEN Shuo, YIN Jun-Kai, FENG Yi-Fei, YUAN Yi-Fang, WU Kai-Jie. The Establishment of Test Platforms for Terahertz Stimulation of Auditory Nerve[J]. Progress in Biochemistry and Biophysics,2022,49(12):2421-2427

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History
  • Received:December 13,2021
  • Revised:February 24,2022
  • Accepted:February 28,2022
  • Online: December 20,2022
  • Published: December 20,2022