Malignant tumors have become serious threatens to human health and life. Although radiation therapy and chemotherapy are commonly used to treat tumors in clinical practice, which could inhibit the growth and metastasis of tumors to a certain extent, but there are still some drawbacks to overcome. For example, the traditional chemotherapy drugs lack targeting and have serious side effects during the administration process. Moreover, most chemotherapy drugs are poorly water-soluble and thus have limited effects, and repeated administration of high doses lead to drug resistance. Importantly, the single-mode treatment strategy does not work well. Recently, the construction of targeted intelligent multi-functional nano-drug carrier system to achieve accurate diagnosis and treatment of tumors has become a research hotspot. Among various materials, porphyrin mental-organic frameworks (MOFs) materials have the characteristics of high porosity, large specific surface area, and surface modification, making it promising platforms for constructing targeted stimulus-responsive drug carrier. Moreover, porphyrin MOFs can avoid self-aggregation of porphyrin molecules and self-quenching in the excited state, and also have a wide spectral response range of porphyrin molecules, which is a class of solid photosensitizers with broad application prospects. Therefore, porphyrin MOFs have become an important platform for building targeted intelligent multifunctional nano-drug delivery systems in recent years. Herein, the recent research progress of porphyrin MOFs-based multifunctional nano-platforms triggered by stimulation of endogenous components (such as pH, enzymes, oxidation reduction species) and exogenous factors (such as sound, magnetism and light) for the precise diagnosis and treatment of tumors in recent years are summarized, and the challenges and opportunities faced by porphyrin MOFs in future tumor treatment are also discussed. Compared to traditional drug delivery systems, endogenous and exogenous stimuli-responsive systems can significantly improve the biosafety and the efficiency of tumor treatment. Typically, multimodal synergistic therapies using porphyrin MOFs as platform, such as combining photodynamic therapy (PDT) with chemotherapy, photothermal therapy (PTT), immunotherapy or sonodynamic therapy could achieve synergistic effects and maximize the therapeutic effect and safety.