1) College of Integrated Chinese and Western Medicine, Hunan University of Chinese Medicine, Changsha 410208, China;2) Andrology Laboratory, Hunan University of Chinese Medicine, Changsha 410208, China;3) The First Clinical College of Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China;4) Hunan Medical College, Huaihua 418000, China;5) Guangxi Scientific Research Center of Traditional Chinese Medicine, Guangxi University of Chinese Medicine, Nanning 530200, China;6.6) The First Hospital of Hunan University of Chinese Medicine, Changsha 410007, China

This work was supported by grants from The National Natural Science Foundation of China (82074444, 81673984), the Special Funds for the Construction of Innovative Provinces in Hunan - “Huxiang Young Talents” Support Program (2019RS2041), the Key Projects of Hunan Provincial Department of Education (20A368), Changsha Science and Technology Plan Project—Changsha Outstanding Innovative Youth Training Program (kq1802015), the Hunan Province High-level Health Talents 225 Engineering Medical Discipline Backbone Talent Training Object (Xiang Wei Han [2019] 196), the China Association of Traditional Chinese Medicine “Young Talent Support Project” of the China Association of Chinese Medicine (2019-QNRC2-C07), the Hunan University of Chinese Medicine First-class Discipline of Integrated Chinese and Western Medicine Open Fund (2020ZXYJH64), and the Hunan University of Chinese Medicine Graduate Innovation Project (2022CX09).