Vol.48,No.8,2021
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Cover Story：As the increasing aging population globally, Alzheimer’s disease (AD) has been the most common
type of neurodegenerative disease, characterized with progressive cognitive impairment. The main pathological
features were senile plaques, neurofibrillary tangles and neurons and synapse loss. Inhibitor of apoptosis family
proteins (IAPs) are a class of endogenous apoptosis inhibitors, and their function in the pathological process of
AD has not been clear. In this study, IAPs protein expression were analyzed from AD patient databases, AD
animal models and brain slice models. NFκB signaling pathway was detected by EMSA and immunoblotting. The
results show that Survivin acts as a co-upregulated gene in all models including AD patients, AD mouse models
and Aβ, okadaic acid and LPS induced brain slices. NFκB signaling pathway was significantly activated, and they
exhibited the similar expression profile. Therefore, the cell apoptosis in AD progression may be inhibited by
NFκB/IAPs axis. Survivin may be an important target for AD prevention and treatment.
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Special Topic: Alzheimer's Research
Reviews and Monographs
Research Papers
Techniques and Methods
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