Human factor Ⅷ is an important cofactor in the intrinsic blood coagulation. Hemophilia A is the most common severe inherited bleeding disease due to the deficiency or abnormality of factor Ⅷ. Factor Ⅷ gene has been successfully cloned and expressed in eukaryotic cells that promotes the studies on the gene mutations of factor Ⅷ widely and thoroughly. This article introduces the recent progress about this field. and new techniques used in researches. The study on gene abnormalities of factor Ⅷ can be regarded as an excellent example both in depth and width for researches of the congenital diseases.