纤维粘连蛋白是一双链结构、由多个功能区构成的大分子糖蛋白.多肽链分子由三种形式的结构模型重复出现所构成,相邻的几个重复结构组成一个功能区.体内仅一条FN基因,经选择剪切产生多种形式的FN多肽,它们之间的区别在于三个可变区氨基酸残基的不同.纤维粘连蛋白参与广泛的病理及生理过程,其功能区结构及基因结构的深入研究,有利于阐明其结构与功能的关系.
Fibronectin (Fn) is a high molecular dimer of glycoprotein with a series of discrete structural domains. It is composed of three type repeats,type Ⅰ,Ⅱand Ⅲ. A serial repeats form a functional domain. There is only one Fn gene in body, and by alternative splicing it produces many kinds of Fn polypeptides. which have different sequences in three variable regions.Fn is involved in a variety of biological functions. It is very important to elucidate the relationship between the function and structure relationship by deeply analysing the structures of its domains and gene.
王玲,王振义,戚正武.纤维粘连蛋白的分子生物学研究[J].生物化学与生物物理进展,1994,21(2):109-112
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