利用病毒和动物系统对基因表达调控进行了广泛和深入的研究,发现了顺式作用调节序列,鉴定了序列专一的DNA结合蛋白,DNA与蛋白质相互识别、结合及蛋白质与蛋白质相互作用中起作用的蛋白质结构域,并且对调节蛋白基因的克隆和序列进行了分析.基因表达调控领域又由于植物基因调控机制取得的发展而得到了补充,文章着重介绍植物基因中的DNA与蛋白质间的作用;植物调节蛋白基因的分离;这一领域的今后研究方向及展望.
Nuclear factors are increasingly important in playing part in regulating the expression of genes. Eukaryotic transcriptional initiation is controlled by complecated interactions between cis-acting DNA motifs and trans-acting proteins, which consist of nuclear factors. Four sequences involved in DNA sequence recognition have been determined as follows; zinc fingers : leucine-zippers; helix-turn-helix and helix-loop-helix motifs. Research from viral and animal systems turn to plant gene expression systems. Evidence has shown that the interaction of nuclear factors is the basis and pre-requisite for the regulation of gene expression.
邵宏波,初立业.基因表达调控中的核因子作用[J].生物化学与生物物理进展,1994,21(2):123-126
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