采用RNA斑点杂交分析,对21例人脑原发性胶质瘤和11例人脑膜瘤中p53,Rb和c-myc基因转录水平的表达进行研究.发现48.4%的肿瘤中p53基因表达减弱,21.9%的肿瘤中Rb基因表达减弱;71.9%的肿瘤中c-myc基因表达增强.在p53基因表达减弱的15例病例中有13例(80%)c-myc基因表达增强.结果表明,p53基因表达减弱和c-myc基因表达增强与人脑原发性肿瘤的发生有关.
21 human primary brain gliomas and 11 human menigiomas were examined with RNA dot blot hybridization for the expression of p53, Rb and c-myc gene. It was found that the level of p53 gene expression is lower in 48.4% (15/31) of the tumors tested than that of normal brain tissues; the level of Rb gene expression is lower in 21.9% (7/32) for the tumors tested than that of normal tissues; and the level of c-myc gene expression is higher in 71.9% (23/32) for the tumors tested than that of normal tissues. Interestingly, in 13 of the tumors tested, the level of p53 gene expression is lower and the level of c-myc gene expression is higher. These results suggested that the expressive decrease of p53 gene and the expressive increase of c-myc gene are relative to the generation of human primary brain tumor.
谭德勇,林晞,孙芝琳. P53,Rb和c-myc基因在人脑原发性肿瘤中的转录表达[J].生物化学与生物物理进展,1994,21(2):175-177
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