Glycophorin(GP or sialoglycophorin)-A,B.C and D constitute a group of red blood cell (RBC) transmembrane proteins.GPA carried the M-and N-blood group antigens. GPB represents the Ss,and U antigens.GPC and GPD exhibit the Gerbich receptors. Some homologious peptide sequences exist in four of the GPs,but extensive similarities are within GPA and GPB family,GPC and GPD family as well.Because of its abundant sialic acid content，GPA plays a critical role in preventing and minimizing interactions of RBC to RBC, and of RBC to other cells in circulation. Binding of a ligand specific for GPA induces profound changes in membrane material behavior. GPC has a important role in regulating RBC shape,membrane deformability and membrane machinical stability. The functions of GPA and GPC are associated with band 3 and 4.1 proteins respectively.