Hypoxia and post-hypoxia reinfusion usually lead to a series of complicated physiological and biochemical changes.Through the model of mouse repetitive hypoxia ,the content changes of gangliosides and monoamine neurotransmitters were observed in the brain and it was found that:with the increment of the anoxic times:①Gangliosides(calculated as NANA)was continuously falling(P<0.01),and the falling of relative percentages of GM1 and GD1b of which were magnificent (GM1:P<0.05,GD1b:P<0.01);②Among monoamine neurotransmitters，the level of NE and DOPA descended and that of DA and HIAA increased (P<0.01).The results point out:after repetitive hypoxia，the cell membrane in centrical nerve tissues is injured in some degree and thus may affect the whole process of synthesizing，releasing，reabsorbing and storing of monoamines. There is association relation between changes of gangliosides and monoamines when hypoxia occurs.