Ras的结构和功能及其参与的信号传导
DOI:
CSTR:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:


The Structure-Function Relaationship and the Signal Transduction Pathway of Ras Protein
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    从ras基因发现以来,因为它和癌症的相关性,引起了人们对其基因和蛋白研究的普遍关注.通过这些研究不仅知道了ras基因的癌变作用机制,而且对Ras蛋白与磷酸化途径的关系有了一个比较清晰的了解.同时关于Ras蛋白所参与的信号传导途径的研究使得对细胞内的整个信息通路的开关和调节有了更进一步的认识.Ras蛋白参与的信号传导途径还和其他的通路有相关性,如G蛋白的β、γ亚基二聚体可以激活Ras途径.因此对Ras途径的研究不仅可以了解Ras自身的调节途径,而且对细胞内整体的信息传导的研究是十分必要的.

    Abstract:

    The ras gene has attracted great attention ever since it has been discovered having a relationship to cancer.Scientists not only know nowadays the mechanism about how ras gene results in cancer but also have a clear understanding about the relationship between Ras protein and the pathway of phosphorylation.In addition,the research about the signal transduction pathway which has something to do with the Ras protein leads to a more detailed understanding about the regulation of information communication in cells. Further more,the signal transduction pathways of Ras and of other proteins interact with each other. For example,the Ras pathway can be activated by the αβ dimer of G protein. Therefore,it is extremely necessary to study the Ras pathway,which will throw great insight on the regulation of Ras itself and the signal transduction on the cell level.

    参考文献
    相似文献
    引证文献
引用本文

熊舜斌,唐朝宇,许根俊. Ras的结构和功能及其参与的信号传导[J].生物化学与生物物理进展,1995,22(6):482-486

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:1994-11-24
  • 最后修改日期:1995-03-16
  • 接受日期:
  • 在线发布日期:
  • 出版日期: