In the extracellular plasmin system,the receptor for a urokinase plasminogen activator (uPAR) acts as an anchorage site for uPA on the cell surface where it modulates the activities of the extracellular plasmin system, has a function of internalizing uPA-inhibitors and other complexes, transmits the extracellular signals into cells and represents a new prognostic parameter and a promising approach for anti-invasive therapy in cancer.