聚腺苷二磷酸核糖基聚合酶(poly (ADP-ribose) polyerase, PARP)是存在于多数真核细胞中的一个蛋白质翻译后修饰酶,它可催化组蛋白H1等重要核蛋白及它自身的聚腺苷二磷酸核糖基化作用.细胞受到外界损伤因子作用时, DNA发生链断裂,PARP结合到DNA断裂口,其催化活性被激活,修饰受体蛋白,进而引发一系列级联反应.这种性质使PARP有可能作为细胞内的分子感受器和传感器,启动细胞内对损伤作出反应的信号传导机制,从而根据细胞受损程度决定细胞的命运:修复或是死亡.
Poly (ADP-ribose ) Polymerase (PARP) is a kind of enzyme which responsible for posttranslation modification of proteins. It exists in many eukaryotic cells and catalyzes poly ADP-ribosylation of nuclear proteins including histone H1 and itself. When cells are damaged by toxic agents that induce DNA breakages, PARP molecules will bind to DNA breakage and their catalytic activity is activated. Then they modify their acceptor protein and trigger a set of cascade reactions. Thus PARP is a possible molecular sensor and transducer to initiate the signal transferring path for reacting to damages of the cell. The information which they passed may decide the fate of a cell: repair or death.
罗瑛,孙志贤,吴祖泽.聚腺苷二磷酸核糖基聚合酶──在DNA损伤修复及程序性死亡中的作用[J].生物化学与生物物理进展,1996,23(4):308-312
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