胆碱酯酶结构与功能及磷酰化酶重活化机理
DOI:
CSTR:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:


Progress in the Studies of Structures and Functions of Acetylcholinesterase and the Reactivation Mechanism of Organophosphate-inhibited Enzyme
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    对近几年来应用计算机模拟和分子生物学定点突变技术研究乙酰胆碱酯酶的结构与功能关系的进展进行了综述,对不同抑制剂的抑制作用机理及重活化药物对不可逆抑制剂有机磷酸酯磷酰化酶的重活化作用机理研究进展也进行了综述.

    Abstract:

    After the elucidation of the threedimensional structure of Torpedo acetylcholinesterase by X-ray diffraction in 1991,studies by computer modelling and site-directed mutagenesis have led to significant progress in the elucidation of the structure-function relationship of this enzyme. And based upon this,efforts have been made to invcstigale further mechanism of inhibition by irreversible inhibilors (organophosphate), and that of the reactivation of the irreversiblly inhibited enzyme. In addition, progress in study of aging nirchanism of the inhibited enzyme was also reviewed.

    参考文献
    相似文献
    引证文献
引用本文

罗春元.胆碱酯酶结构与功能及磷酰化酶重活化机理[J].生物化学与生物物理进展,1996,23(4):329-333

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:1995-10-12
  • 最后修改日期:1996-01-18
  • 接受日期:
  • 在线发布日期:
  • 出版日期: