用固相pH梯度(pH 5.05~5.60)等电聚焦技术对随机抽取的188名北京地区健康汉族人的血清转铁蛋白(Tf)进行分型调查,并统计基因频率,检出了在中国还未见报道的TfC3基因.其表型分别是:TfC1, TfC2, TfC1C2, TfC1C3, TfC1Dchi, TfC2Dchi.TfC1=0.7420, TfC2=0.2420, TfC3=0.0027, TfDchi=0.0133, 符合Hardy-Weinberg定律, 并与其他已见报道的汉族 Tf基因频率大致相符.
Six phenotypes TfC1, TfC2, TfC1C2, TfC1C3, TfC1Dchi and TfC2Dchi were detected by isoelectric focusing with immobilized pH gradients in pH 5.05~5.60. TfC3 has never been revealed in the Han population before. The Gene frequencies are as follows: TfC1=0.7420, TfC2=0.2420, TfC3=0.0027, TfDchi=0.0133. There is a good agreement between the observed and expected values corresponding to the Hardy-Weinberg equilibrium. The allele frequencies for TfC1, TfC2 and TfDchi are quite similar to those previously reported.
郭尧君,李辛晖,朱海珍,沈子威.转铁蛋白分型及其基因频率分布[J].生物化学与生物物理进展,1997,24(6):540-543
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