蛋白酶体是真核细胞内依赖ATP的蛋白质水解途径的重要成分,负责大多数细胞内蛋白质的降解. 20 S蛋白酶体有多种肽酶活性,其活性位点为Thr. 19 S复合物与20 S蛋白酶体结合成为26 S复合物,能降解泛素化蛋白.近几年来,蛋白酶体的分子组成、亚基、生化机理、胞内功能等方面的研究取得了明显进展.
The proteasome is an essential component of the ATP-dependent proteolytic pathway in eukaryotic cells and is responsible for the degradation of most cellular proteins. The 20 S proteasome whose active site is a threonine,contains multiple peptidase activities. PA700 cappes the 20 S proteasome to form the 26 S complex, by which ubiquitinated proteins are degraded. Advances have been achieved recently in the research about the molecular organization of the 20 S and 26 S particles,their subunits,their intracellular functions and biochemical mechanisms.
彭睿,秦浚川,宋晓龄.蛋白酶体结构和功能研究进展[J].生物化学与生物物理进展,1998,25(3):235-238
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