真核细胞端粒DNA序列的丢失与细胞的衰老及凋亡有关.端粒酶的激活可维持端粒长度并使细胞获得无限增殖的能力.端粒结合蛋白则可能通过调节端粒酶或其他相关因子的行为参与对端粒长度的调控.近年有关端粒结合蛋白的研究取得了突破性进展并在此基础上建立了端粒长度调控模型.
Loss of telomere DNA repeats in eukaryotic cells is associated with senescence and apoptosis.Activation of telomerase can maintain telomere length stability and make cells immortal.Telomere-binding proteins might regulate the length of telomere by means of regulating telomerase or other relative factors.The progress in study of telomere-binding proteins and the model of telomere length regulation based on it are reviewed.
陈耿,周建新,董燕麟.端粒结合蛋白与端粒长度调控[J].生物化学与生物物理进展,1999,26(5):419-422
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