从鼠肝cDNA文库克隆了一个新的STE20类蛋白激酶,Mess1.其cDNA长1.7 kb,编码了一个497个氨基酸残基的多肽,与人MST2具有95%的氨基酸相同.Mess1蛋白氨基末端激酶催化区的序列与STE20同源,其羧基末端包含了一簇丝氨酸/苏氨酸和谷氨酸丰富的序列,被认为具有介导与SH2功能区结合的作用.MESS1可能通过与含有SH2功能区的蛋白质相互作用参与细胞内信号转导.
A novel STE20-like protein kinase, Mess1, was cloned from a murine liver cDNA library. The 1.7 kb cDNA encodes a peptide of 497 amino acids. Mess1 is most similar to human MST2 protein kinase with an identity of 95%. A putative kinase catalytic domain, located at the amino terminus of the Mess1 protein, is homologous to that of the STE20 family. There is a serine/threonine and glutamic acid-rich cluster in the carboxyl terminal region of Mess1 that is believed to mediate the binding of SH2 domains. Mess1 might involve the signal transduction on the interaction with proteins with SH2 domains.
姜勇,韩家淮,顾军.一个新的鼠STE20家族激酶的克隆和鉴定[J].生物化学与生物物理进展,1999,26(5):464-468
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