尿中游离L-岩藻糖测定的临床应用
DOI:
CSTR:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:


Clinical Application for Determination of Free L-FC in Urine
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    采用日本宝酒造公司生产的L-岩藻糖监测试剂盒及质控标准品,用酶分析法在自动生化分析仪上对86例正常健康者和205例不同肿瘤患者尿中的UFC水平进行检测,结果显示,健康组尿中UFC水平:x=177.7,s=56.6,95%,可信限范围是63.8~290.2 μmol/g.cr;肝癌、肝硬化、急慢性肝炎、胰腺癌、食管癌、胃癌、肠癌、肺癌患者尿中UFC均值大于290 μmol/g.cr.与正常健康组对照,有非常显著性差异;乳腺癌、宫颈癌、卵巢癌患者的UFC与健康组比较,有显著性差异.尿中游离L-岩藻糖测定方法简便、快速、能自动化、取样方便,并提示尿中UFC水平的变化可视为肝癌、急慢性肝炎癌变的特异性指标之一,也是消化系统癌症病人肿瘤标记物试验之一.

    Abstract:

    L-fucose (L-FC),6-deoxygalactose, is one of rare sugars which naturally exists in the form of L-isomer. L-fucose plays an important role in their physiological and biological functions. It has been well known that L-FC is attached to glycochains of tumor markers such as alpha fetoprotein (AFP) and CA-199. Increment of α-L-fucosidase was detected in patients with primary hepatic carcinoma. Fucolipid accumulation in human adenocarcinoma was abnormally increased and fucosyltransferase was highly active in lung cancer cells. In addition,it has been found that patients with liver cancer and cirrhosis excreted free L-fucose via urine to greater extent than normal individuals. The values of UFC were detected in the urine from 86 health people and 205 people with various tumors. The mean value of urinary L-FC in health people was 177.7 μmol/g.cr(s=56.6, 95% confidence range was 63.8~290.2 μmol/g.cr). The mean values of UFC in urine obtained from patients with hepatocellular carcinoma, cirrhosis, acute and chronic hepatitis, pancreas carcinoma, gastric cancer, lung cancer , intestinal cancer, esophageal cancer were higher than 290.2 μmol/g.cr, having significant difference from normal individuals. The mean values of UFC in urine obtained from patients with mastadenoma, cervical cancer and ovary cancer have significant difference from normal individuals. The value of L-fucose in urine can be regarded as one of the characteristic indexes for hepatocellular carcinoma and canceration of acute and chronic hepatitis. Detection for L-fucose is one of tumor marker tests for patients with tumor in digestive system.

    参考文献
    相似文献
    引证文献
引用本文

宋耀虹,冯涛,沈瑛,马德均,王惠珍.尿中游离L-岩藻糖测定的临床应用[J].生物化学与生物物理进展,1999,26(5):511-514

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:1998-10-06
  • 最后修改日期:1999-03-15
  • 接受日期:
  • 在线发布日期:
  • 出版日期: