中国科学院重大项目“神经科学前沿课题的开拓”资助项目(9002KP85-2-4).
利用乙酰胆碱( acetylcholine,Ach)自身抗体对金黄地鼠视皮层17、18区乙酰胆碱阳性神经元及其分布进行免疫学显示并进行量化分析.实验发现,Ach阳性细胞大部分为非锥体神经元,也有少量锥体神经元.Ach阳性神经元在视皮层的Ⅱ~Ⅵ层,主要分布在Ⅱ~Ⅳ层.在不同层次中其阳性神经元类型存在某些差异,Ⅱ~Ⅳ中双极细胞居多,其他层次中多极细胞占优势.17区的这类神经元数量较多且集中成垂直于皮层表面的细胞带,18区的神经元数量相对较少且多呈分散状态.
Acetylcholine localization was studied immunohistochemically in neurons of the area 17 and 18 in the hamster visual cortex using anti-acetylcholine serum. It was found that the Ach-labeled cells are nonpyramidal neurons primarily and a few pyramidal neurons also exist. These neurons were found to be distributed in layer Ⅱ~Ⅵ, concentrated in the layer Ⅱ~Ⅳ. The neurons in the area 17 having greater density are arranged to form a columns perpendicular to the surface of the visual cortex and the neurons in the area 18 having smaller density are distributed dispersely. In the different layers of the visual cortex, the type of stained neurons has variation with that the majority of these neurons were bipolar in layer Ⅱ, Ⅳ and the multipolar cells in the other layers.
李俊凤,吴奇久.金黄地鼠视皮层17、18区乙酰胆碱阳性神经元[J].生物化学与生物物理进展,1999,26(6):587-590
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