神经系统特异表达基因调控机理的研究进展
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Transcriptional Regulation of Neuronal-specific Gene Expression
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    摘要:

    神经系统特异性基因正确的时空表达受细胞内外信号的调控,信号传导途径最终的靶位点是能结合特异转录因子的DNA序列.目前发现的决定神经系统基因特异性表达的顺式作用元件既有增强子,也有沉默子.它们可以特异性地增强基因在神经系统的表达,或特异性抑制基因在非神经系统的表达. 顺式元件要发挥这些作用,依赖于与其结合的反式因子,而这些反式因子又能与其他蛋白质或DNA序列发生互动, 通过协调作用,共同决定基因的时空表达顺序.

    Abstract:

    The differentiating of neurons and other distinct cell types during embryonic development requires the selective activation or repressing of many different sets of genes. Gene expression patterns in neurons are modulated by multiple extracellular and intracellular stimuli. The transcriptional regulation of individual gene is mediated by small DNA sequences such as silencer and enhancer, and the expression pattern can be determined by the integration of the effects of a very large number of these cis-acting elements. These DNA elements either activate or repress promoter activity depending upon the nature of the transcription factors that bind to them . It is possible that there are different regulatory mechanisms of gene expression in the nerve system.

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刘瑾,袁建刚,强伯勤.神经系统特异表达基因调控机理的研究进展[J].生物化学与生物物理进展,2001,28(1):7-10

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  • 收稿日期:1999-11-17
  • 最后修改日期:2000-01-29
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