国家重点基础研究专项(G1999055903)、国家九五“攀登预选项目”(970211019-3)、中国科学院“百人计划”和计划生育生殖生物学国家重点实验室资助.
This work was supported by a grant from the Special Founds for Major State Basic Research Project(G1999055903), The Climbing Project of China(970211019-3) and the 100-Scientist-Program of the Chinese Academy of Sciences.
焦点粘着激酶是依赖于整合素的细胞信号转导通路的基础性信号传递分子.通过磷酸化酪氨酸位点和富脯氨酸序列,活化的焦点粘着激酶与细胞骨架蛋白、Src族激酶、磷酸肌醇-3激酶、Graf以及多种衔接子蛋白相互作用,调节细胞的粘附、迁移、增殖和分化.
Focal adhesion kinase is a non-receptor protein tyrosine kinase with molecular weight 125 ku and regarded as the foundmental molecule of integrin-dependent signal transduction pathway. Active focal adhesion kinase regulates cell adhesion, migration, proliferation and differentiation by interacting with Src family kinase, phosphatidylinositol-3 kinase, cytoskeletal proteins, Graf and adoptor proteins through the phosphorylated tyrosines and the proline-rich sequences.
铁国栋,段恩奎,赵兴绪.焦点粘着激酶的研究进展[J].生物化学与生物物理进展,2001,28(1):22-25
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