This work was surpported by fund of president of Chinese Academy Sciences.
胎盘滋养层是直接与母体接触的与母体基因型不同的胎儿组织,滋养层细胞是否表达主要组织相容性复合体(MHC)抗原以及表达何种MHC抗原对于妊娠成功与否至关重要.非经典MHCⅠ类抗原发现较晚,其中HLA-G在滋养层细胞表达,可以保护带有父方同种异体抗原的胎儿免受母体免疫系统的杀伤.经典MHCⅠ类抗原有多种亚型,不同亚型在滋养层细胞的表达有所不同.MHCⅡ类抗原在妊娠维持过程中表达极弱,新近的研究资料表明,滋养层细胞CⅡTA在MHCⅡ类基因表达调控中起主要作用.
The trophoblast is fetal-derived and in direct contact with maternal tissues. The expression of the various types of MHC antigen in trophoblast cells is very important for successful pregnancy. Among nonclassical MHC class Ⅰ antigens, HLA-G is expressed specifically on cytotrophoblast cells and its expression protects the fetal from maternal immune attack. The expression of the distinct subtypes of classical MHC class Ⅰ antigen is different in different subtypes of trophoblast cells. The expression of MHC class Ⅱ antigen is inhibited in trophoblast during pregnancy. It is suggested that CⅡTA plays an important role in regulation of MHC class Ⅱ gene expression.
刘喆,彭景楩,祝诚.滋养层细胞表面主要组织相容性复合体抗原的研究进展[J].生物化学与生物物理进展,2001,28(1):26-28
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