短肽蝎毒素的结构分类与功能特征
DOI:
CSTR:
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:

国家自然科学杰出青年基金资助项目(39625010).


Structural Classification and Functional Characterization of Short-Chain Scorpion Toxic Peptides
Author:
Affiliation:

Fund Project:

This work was supported by a grant from National Natural Sciences Foundation of China (39625010).

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    大量的资料已证实蝎毒中主要致死成分是一类由60~70个残基组成, 选择性地作用于电压门控Na+通道的长肽毒素.另一类由30~40个残基组成的短肽蝎毒素,由于其具有结构致密,易于合成改造的优点,特别是具有选择性地阻遏K+或Cl通道的特异药理功效,近年来倍受学术界的关注,并在结构与功能方面取得了很大的研究进展.

    Abstract:

    Recent research has revealed that scorpion venom contains short-chain peptides with the specificity on K+ or Cl channels, in addition to the knowledge of many kinds of long-chain peptides with the specificity on Na+ channels. According to the similarity of molecular structure and/or function, they have been classified into several groups. These short-chain scorpion peptides are playing more and more important role in studying the structure and function of K+ or Cl channels. The advance of structure and function of short-chain scorpion peptides in recent years was briefly introduced.

    参考文献
    相似文献
    引证文献
引用本文

陈冰,吉永华.短肽蝎毒素的结构分类与功能特征[J].生物化学与生物物理进展,2001,28(1):44-48

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2000-01-09
  • 最后修改日期:2000-02-29
  • 接受日期:
  • 在线发布日期:
  • 出版日期: