This work was supported by a grant from National Natural Sciences Foundation of China (39625010).
大量的资料已证实蝎毒中主要致死成分是一类由60~70个残基组成, 选择性地作用于电压门控Na+通道的长肽毒素.另一类由30~40个残基组成的短肽蝎毒素,由于其具有结构致密,易于合成改造的优点,特别是具有选择性地阻遏K+或Cl-通道的特异药理功效,近年来倍受学术界的关注,并在结构与功能方面取得了很大的研究进展.
Recent research has revealed that scorpion venom contains short-chain peptides with the specificity on K+ or Cl- channels, in addition to the knowledge of many kinds of long-chain peptides with the specificity on Na+ channels. According to the similarity of molecular structure and/or function, they have been classified into several groups. These short-chain scorpion peptides are playing more and more important role in studying the structure and function of K+ or Cl- channels. The advance of structure and function of short-chain scorpion peptides in recent years was briefly introduced.
陈冰,吉永华.短肽蝎毒素的结构分类与功能特征[J].生物化学与生物物理进展,2001,28(1):44-48
复制生物化学与生物物理进展 ® 2025 版权所有 ICP:京ICP备05023138号-1 京公网安备 11010502031771号