胞外信号可经过相应的转导途径传至胞内,通过激活靶分子而产生细胞效应.细胞凋亡是受控于生物体精确调节的细胞主动消亡过程,具有独特而复杂的信号系统.特异性的胞膜蛋白及膜脂等皆可介导凋亡相关分子的级联激活,并通过活化凋亡关键调节分子Caspases蛋白酶家族,bcl-2基因家族及线粒体等而影响凋亡的进程.
A variety of extra-cellular signals could activate the target molecules and induce the associated biological effects depended on different signal pathways. Apoptosis,or programmed cell death, is a conservation process essential for normal development and homeostasis of biologist. It's known that a number of factors and pathways can lead to apoptosis. Specific phosphorlipids and proteins of biomembrane could activate the signal cascades of apoptosis. The interaction of caspases, bcl-2 family and mitochondria play an essential role in regulation of apoptosis.
辛宏,颜光涛,陈泮藻.生物膜信号转导与细胞凋亡[J].生物化学与生物物理进展,2001,28(1):52-55
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