紫膜中具有质子泵功能的菌紫质(bR)是整合膜蛋白,它是7个α螺旋跨膜蛋白家族的基本原型.目前,具有光驱动质子泵的bR是最典型的高效离子转运蛋白之一.它很可能成为其载体转运机制在分子甚至原子水平上被阐明的第一个膜蛋白.概述了近年来对菌紫质结构,光循环和质子泵机理研究的进展.
Bacteriorhodopsin(bR) in the purple membrane with the function of proton pumping is an integral membrane protein, and it is a prominent prototype of the family of seven α-helical proteins. At present, bR with light-driven proton pump is one of the best char1acterized active ion-translocating proteins. It is very possible that bR will be the first membrane protein whose vectorial transport mechanism is understood at the molecular and even atomic level. The progress on the structure, photocycle and proton pump of bR in recent years are briefly introduced.
万逢义,胡坤生.菌紫质的结构和功能研究进展[J].生物化学与生物物理进展,2001,28(3):342-347
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