Bio-cell sensor and bio-cell chip techniques have been important tools in post-gene era.They can detect functional information of cells as well as nature of matters detected.Living cells would be detected as a unit or sensetive element by exchanging between biological signals and physical and electrochemical signals.The detection using these tools is raptive,in real-time,quantitive and qualitive. Bio-cell sensor and bio-cell chip techniques have been applied in fields of the cellular biology,the monitoring of envirement and the developments of drugs.The developments of methods,applications in three years and the trends are reviewed.