MAPK (mitogen-activated protein kinase) family, which is conserved throughout high eukaryotes, is implicated in multiple cellular processes including cell growth, migration, proliferation, differentiation, survival and development. Pathogen hijacks hosts' MAPK pathways to facilitate its pathogenesis using diverse strategies. To further explore the mechanism underlying interactions between pathogens and hosts' MAPK pathway, is of benefit to our understanding of nature as well as to our fight against pathogen infection.