This work was supported by a grant from Doctoral Found of Henan Institute of Science and Technology(6002).
综述了IAV逃避抗病毒免疫策略的最新进展.A型流感病毒(IAV)感染是人和多种动物呼吸系统疾病的主要原因,然而不管是IAV引起的季节性流感暴发还是周期性的全球流感大流行,主要归因于IAV逃避宿主免疫反应的策略.越来越多的证据表明,IAV已经进化出高超的策略克服宿主的抗病毒信号,如抗原变异和编码辅助蛋白(NS1和PB1-F2).深入理解IAV逃避宿主免疫的策略,有助于揭示IAV感染的机制和发现针对IAV的抗病毒药物的靶标.
Influenza A virus(IAV) infection is a major cause of respiratory disease in human and many kinds of animals, however, either seasonal“flu” outbreaks or periodic world-wide pandemics caused by IAV is mainly attributed to strategies exploited by IAV for evading antiviral immune responses of the host. There is growing evidence that IAV has evolved highly sophisticated strategies to overcome the antiviral signaling, such as antigen variation and encoding accessory proteins(NS1 and PB1-F2). A better understanding of the strategies exploited by viruses for evading the immunity is helpful for us to reveal the pathogenesis of IAV infection and discover targets for the development of antiviral reagents directed against IAV. Therefore,the latest progress on strategies exploited by IAV for evading antiviral immunity are reviewed.
赵朴,郑玉姝,乔传玲,贾贝贝,刘兴友. A型流感病毒逃避免疫应答的策略[J].生物化学与生物物理进展,2008,35(10):1137-1141
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