The LASP-1 gene was initially identified from a cDNA library of metastatic axillary lymph nodes (MLN) from human breast cancer. The Lasp-1 gene encoded a putative protein containing a LIM motif at its amino terminus and a src homology 3 (SH3) domain at its C-terminal part. Overexpression of LASP-1 has been reported in many kinds of malignant tumors, such as breast cancer and ovarian cancer. LASP-1 is closely related to genesis, invasion and metastasis of tumor. Recently, LASP-1 was identified as a novel transcriptional target of tumor suppressor gene p53. On the basis of the existing data, LASP-1 is a novel tumor suppressor protein.