Parkinson's disease (PD) is the most frequent progressive neurodegenerative movement disorder, and autosomal dominant inherited PD can be caused by LRRK2 mutations. The new findings of LRRK2's function were summarized and described in 10 aspects, such as molecular genetics, expressing distribution and subcellular localization, function of mutants, protein chemistry, protein dynamics, interacting protein and substrate, signal transduction pathway, connection with neurite and synaptic vesicles protein, structure analysis, pathological and clinic features. It was pointed out that these achievements have preliminarily clarified the pathogenic mechanism of how LRRK2 mutants cause PD, and presented the new strategies for treatment of PD. Finally, the future researches were previewed.