Ageing, as an ineluctable physiological process for all organisms, is a complex life activity induced by several factors. Currently yeast cell becomes an ideal model organism which is generally acknowledged, and many mechanisms and regulatory factors have been discovered by the insightful research of yeast. One of its well-established ageing models，called chronological ageing, is conserved with other higher eukaryotic cells，especially mammalian cells, thus attracted much attention on such a study. Two ageing models in yeast were compared, the research progress in the studies on the molecular mechanisms of yeast chronological ageing was introduced, and several complicated regulatory pathways were expounded including the effects given by calorie restriction and medicine addition on Ras/PKA, Sch9 and Tor regulatory pathways which are nutrient-dependent. Meanwhile, some significant future issues in this field are mentioned and anticipated as reference to dig much further in the comprehensive understanding of the ageing mechanisms in higher living organisms, especially human beings.