Department of Biology, Dezhou Universit
This work was supported by a grant from the National Natural Science Foundation of China ( 30901023)
人们普遍认为,细胞中RNA的转录只能从NTP起始,但最近发现转录其实也可以从一种小RNA—nanoRNAs起始. 细胞中,NTP起始的转录与nanoRNAs起始的转录之间可能存在一个平衡,改变这个平衡会显著影响细胞整体的基因表达水平. nanoRNAs起始转录现象的发现,挑战了人们在分子生物学方面的一些传统认识,如对转录起始的方式、小RNA的作用机制及其RNA降解与RNA转录的偶联关系等,这也为进一步深化分子生物学的研究提供了新契机.
It has been widely assumed that, in vivo, all the initiation of RNA transcription occurs using NTPs only, but it was observed recently that one kind of smalls RNA, nanoRNAs, could also serve as primers for transcription initiation. Perhaps a balance exists between nanoRNA-initiated transcription and NTP-initiated transcription, and altering this balance could significantly impact the global gene expression. The phenomenon of nanoRNAs initiation transcription challenged a few of traditional understandings in molecular biology, such as transcriptional initiation,the functional mechanisms of small RNAs and coupling relations between RNA decay and RNA transcription, thips henomenon also provided a new opportunity of deepening the research in molecular biology.
谢兆辉.转录起始于NTP,还是nanoRNAs?[J].生物化学与生物物理进展,2012,39(12):1174-1177
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