中国科学院动物研究所生物膜与膜生物工程国家重点实验室移植生物学研究组,中国科学院动物研究所生物膜与膜生物工程国家重点实验室移植生物学研究组
Transplantation Biology Research Division, State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences,Transplantation Biology
CD4 CD25 调节性T细胞(Treg)对维持自身免疫耐受及调控免疫应答水平发挥非常重要的作用.Treg的缺失或紊乱导致如多发性硬化症、1型糖尿病等自身免疫性疾病的发生.研究发现,Treg在肿瘤免疫、感染免疫和移植免疫耐受中也发挥关键作用.根据来源不同,可将Treg分为胸腺来源的天然型Treg(natural Treg)和外周诱导型Treg(induced Treg)两群.天然型Treg(nTreg)是由胸腺发育分化成熟的,nTreg存在于胸腺CD4单阳性细胞中,表达CD4、CD25及叉头转录因子Foxp3,主要通过细胞与细胞之间直接接触发挥免疫抑制功能.研究表明,nTreg在胸腺中发育分化受到十分复杂的细胞、分子网络调控.胸腺微环境、T细胞受体、共刺激分子、IL-2等信号都可影响nTreg的发育分化.本文将主要对胸腺nTreg的发育分化过程及分子调控等方面进行综述.
CD4 CD25 regulatory T cells (Treg cells) play crucial roles in the maintenance of self-immune tolerance. Decreased numbers or functional deficiency of Treg cells result in development of a variety of autoimmune diseases like multiple sclerosis and typeⅠ diabetes. Moreover, Treg cells have been implicated in inflammation and transplantation settings. Two types of Treg cells including thymic-derived natural Treg (nTreg) and peripheral induced Treg (iTreg) cells have been identified based on their distinct developmental origin. nTreg cells are derived in the thymus and express high level of Forkhead transcription factor Foxp3, nTreg cells exhibit the suppressive function mainly in a cell-cell contact manner. nTreg cells develop in two steps largely shaped by TCR, co-stimulatory and cytokines in the thymus. In the present manuscript, we will mainly summarize recent advances regarding molecular and cellular regulation of nTreg development and differentiation.
陈辉,赵勇.天然型调节性T细胞发育分化的研究进展[J].生物化学与生物物理进展,2013,40(12):1186-1192
复制生物化学与生物物理进展 ® 2025 版权所有 ICP:京ICP备05023138号-1 京公网安备 11010502031771号