心律失常教育部重点实验室同济大学,心律失常教育部重点实验室(同济大学),同济大学医学院,心律失常教育部重点实验室,同济大学医学院
国家重点基础研究发展计划(973)(2013CB531100), 国家自然科学基金委员会创新研究群体项目(81221001), 国家自然科学基金委员会重大国际(地区)合作项目(81120108004), 同济大学医学院扬帆计划项目(2012YF05)资助
Key Laboratory of Arrhythmias,Ministry of Education Tongji University,Key Laboratory of Arrhythmias,Ministry of Education Tongji University,Key Laboratory of Arrhythmias,Ministry of Education,Tongji University
This work was supported by grants from The National Basic Research Program of China (973 Program) (2013CB531100), Foundation for Innovative Research Groups of The National Natural Science Foundation of China (81221001), The Major International Joint Research Program Fund of China (81120108004) and Yangfan Project of Tongji University School of Medicine (2012YF05)
核膜血影重复蛋白(Nesprins)连接细胞核与多种细胞骨架和(/或)细胞器,在细胞核与细胞骨架定位、质-核间物质运输和动力传导、核膜构建、细胞迁移、锚定和极性建立等过程中发挥重要作用.本文综述核膜血影重复蛋白的发现、编码基因、结构、功能以及与相关疾病的关系研究现状,并展望潜在的未来研究动向.
The nuclear envelope spectrin repeat proteins (Nesprins), connecting the nucleus with many kinds of cytoskeleton and/or organelles, play important roles in nucleus and cytoskeleton positioning, power and material transporting between nucleus and cytoplasm, nuclear envelope constructing, cell migrating, anchoring and polarizing. Their discoveries, encoding genes, structural characters, functions and related diseases were summarized in this review, and their further research pulses are also prospected meanwhile.
赵春霞,崔映宇,陈义汉.核膜血影重复蛋白研究进展[J].生物化学与生物物理进展,2014,41(4):337-344
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