综述: MicroRNA与细胞信号通路的相互作用
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中山大学基因工程教育部重点实验室,中山大学基因工程教育部重点实验室,中山大学基因工程教育部重点实验室,中山大学基因工程教育部重点实验室,中山大学基因工程教育部重点实验室

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国家自然科学基金资助项目(31200593, 81070589, 31230042),国家重点基础研究发展计划(973)资助项目(2011CB811300)


Review: The Reciprocal Interactions of microRNAs and Cell Signaling Pathways
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Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory for Biocontrol, Sun Yat-sen University, Guangzhou 510275, China,Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory for Biocontrol, Sun Yat-sen University, Guangzhou 510275, China,Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory for Biocontrol, Sun Yat-sen University, Guangzhou 510275, China,Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory for Biocontrol, Sun Yat-sen University, Guangzhou 510275, China,Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory for Biocontrol, Sun Yat-sen University, Guangzhou 510275, China

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This work was supported by grants from The National Natural Science Foundation of China(31200593, 81070589, 31230042), National Basic Research Program of China (2011CB811300)

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    摘要:

    MicroRNA(miRNA),广泛存在于多种生物中,在基因表达调控的转录后水平上发挥着重要的调节作用.细胞信号通路转导外界刺激进而引发一系列生理和病理效应,决定着细胞的功能和命运.而miRNA和细胞信号通路间的相互作用对于二者的功能发挥起着关键作用,本文将从信号通路对miRNA的调控和miRNA对信号通路的调节两方面综述二者的相互作用,揭示整合miRNA的细胞信号通路及其生物学意义.

    Abstract:

    MicroRNAs(miRNAs), widely existed in various organisms, play important roles in the regulation of gene expression at the post-transcriptional level. Cell signaling pathways transduce extracellular stimuli into cells and provoke a series of physiological and pathological effects, resulting in cell fate determination. This review summarizes the reciprocal interactions of microRNAs and cell signaling pathways, revealing a miRNA-integrated signaling pathways and network in cells.

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李 斌,郭燕华,徐辉,周惠,屈良鹄.综述: MicroRNA与细胞信号通路的相互作用[J].生物化学与生物物理进展,2013,40(7):593-602

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历史
  • 收稿日期:2013-06-09
  • 最后修改日期:2013-06-09
  • 接受日期:2013-07-03
  • 在线发布日期: 2013-07-24
  • 出版日期: 2013-07-20