综述——纳米材料与药物输递:经皮给药中纳米制剂与皮肤的质构效关系
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中国海洋大学 海洋生命学院,中国海洋大学 海洋生命学院,中国海洋大学 海洋生命学院

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国家自然科学基金(31240007),山东省优秀中青年科学家科研奖励基金(BS2012SW024)和教育部博士点新进教师基金(20120132120011)资助项目


Review: Component-Structure-Effect Correlation Between Nano-Formulations and Skin Tissue in Transdermal Drug Delivery
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College of Marine Life Science, Ocean University of China,College of Marine Life Science, Ocean University of China,College of Marine Life Science, Ocean University of China

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This work was supported by grants from The National Natural Science Foundation of China (31240007), Shandong Youth Scientist Awards Foundation (BS2012SW024) and Programs Foundation of Ministry of Education of China (20120132120011)

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    摘要:

    皮肤是人体最大的器官,也为药物的递送提供了重要途径.经皮给药是药物以皮肤为媒介,透过皮肤吸收的途径.因此,皮肤角质层是经皮给药的最大限速障碍.纳米经皮给药系统具有透皮效率高、缓释性、避免药物肝脏首过效应、副作用少等优点,是通过纳米制剂与皮肤组织之间的相互作用实现的.其中,纳米制剂的结构和组分与其发挥皮肤促渗效用密切相关.深入透彻地了解纳米制剂与皮肤质构效关系,有助于新型透皮纳米制剂的设计,有助于利用综合手段构建安全、高效、实用的经皮给药系统.

    Abstract:

    Skin is the largest organ of human offering important pathway for drug delivery. Drug delivery through transdermal pathway have to penetrate through the skin tissue to realize absorption, thereinto, stratum corneum turns out to be the largest barrier to accomplish transdermal drug delivery. Owing to the specific interactions between nano-formulations and skin tissue, transdermal nanocarrier could provide advantages, such as improving skin penetrating efficiency, sustaining release, avoiding the first-pass effect, decreasing side effects, etc. The structures and components of nano-formulations play crucial roles in enhancing skin penetration. A better and more comprehensive understanding of the correlations between them is not only favorable for the design of novel transdermal nanocarrier, but also beneficial to establish safe, efficient and functional transdermal drug delivery system.

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引用本文

孔明,程晓杰,陈西广.综述——纳米材料与药物输递:经皮给药中纳米制剂与皮肤的质构效关系[J].生物化学与生物物理进展,2013,40(10):1023-1030

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历史
  • 收稿日期:2013-06-13
  • 最后修改日期:2013-08-20
  • 接受日期:2013-08-21
  • 在线发布日期: 2013-10-23
  • 出版日期: 2013-10-20