广东省医学分子诊断重点实验室,广东省医学分子诊断重点实验室,广东医学院生物化学和分子生物学研究所,广东医学院生物化学和分子生物学研究所,广东医学院生物化学和分子生物学研究所
国家自然科学基金资助项目(81272434),国自然科学基金青年项目(81201710),广东省自然科学基金资助项目(S2012010008259)和广东医学院建博科技创新团队项目(STIF201105)
Institute of Biochemistry and Molecular Biology,Guangdong Madical College,Institute of Biochemistry and Molecular Biology,Guangdong Madical College,Institute of Biochemistry and Molecular Biology,Guangdong Madical College,Institute of Biochemistry and Molecular Biology,Guangdong Madical College,Institute of Biochemistry and Molecular Biology,Guangdong Madical College
This work was supported by grants from The National Natural Science Foundation of China(81272434, 81201710), Natural Science Foundation of Guangdong Province(S2012010008259) and Jianbo Technology Innovation Subject of Guangdong Medical College(STIF201105)
上皮间充质转化是上皮细胞丢失细胞极性和细胞黏附,而获得间充质细胞迁移和侵袭特性的生物学过程.肿瘤干细胞是存在于肿瘤中具有自我更新和异质性分化能力的一小群细胞,在肿瘤的发生发展过程中起重要的作用.上皮间充质转化(EMT)与肿瘤的转移密切相关,而近几年的研究表明,EMT也可以促进肿瘤细胞获得干细胞的特性,因此使肿瘤治疗更困难,本文对EMT促肿瘤干细胞形成机制及其对临床治疗意义的研究进展作一综述.
The epithelial mesenchymal transition(EMT)confers mesenchymal properties, migration and invasion on epithelial cells which normally is polarized and interacts with basement membrane via its basal surface. Cancer stem cell is a small subset of stem-like cells which have the capacity for self-renewal and asymmetric cell division. They play an important role in cancer initiation and progression. In rencent years, some researches reveal that EMT, which is closely related tumor metastasis, can generate tumour cells with propreties of stem cells. We review here recent observations correlated with the mechanism of it and its significance to clinical therapy.
蔚帅帅,马晓娟,林碧华,李继霞,周克元.上皮间充质转化促进肿瘤细胞干性获得的研究进展[J].生物化学与生物物理进展,2014,41(7):632-639
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