Review: mTOR Signaling in Aging and Aging-associated Diseases
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Second Xiangya Hospital, Central South University
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摘要:
衰老引起多器官功能衰减，导致各种衰老相关代谢、心血管重大疾病发生和发展．哺乳动物雷帕霉素靶蛋白/雷帕霉素机能靶蛋白(mammalian/mechanistic target of rapamycin，mTOR)信号通路作为生长、发育、代谢、免疫、癌症等生理活动的主要调控者，通过影响细胞自噬、内质网应激、线粒体等形成复杂调控网络，在衰老与长寿中发挥关键作用．mTOR信号通路与许多衰老相关重大疾病(如代谢综合征、心血管疾病、神经退行性病变、 肿瘤等)的发生发展密切相关，故以mTOR为靶点的药物开发与应用是未来延缓衰老及治疗衰老相关疾病的热点之一．
Abstract:
Aging causes a general decline in physiological function that leads to various metabolic and cardiovascular diseases. The links between aging and aging-associated diseases remain to be fully established，but recent studies demonstrate that suppressing the mammalian/mechanistic target of rapamycin (mTOR) signaling pathway extends longevity and delays aging-associated metabolic and neurodegenerative diseases. As a key regulator of metabolism and aging，the mTOR signaling pathway has now become a hot spot for the development of effective therapeutic treatment for aging and aging-related diseases.
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