北京大学第六医院,北京大学第六医院,北京大学第六医院,北京大学第六医院,北京大学第六医院,北京大学第六医院
北京市科技计划重点项目(D121100005012004)资助
Peking University Sixth Hospital,Peking University Institute of Mental Health,Key Laboratory of Mental Health,Ministry of Health Peking University,Peking University Sixth Hospital,Peking University Institute of Mental Health,Key Laboratory of Mental Health,Ministry of Health Peking University,Peking University Sixth Hospital,Peking University Sixth Hospital,Peking University Sixth Hospital,Peking University Sixth Hospital,Peking University Institute of Mental Health,Key Laboratory of Mental Health,Ministry of Health Peking University
This work was supported by a grant from Beijing Municipal Science and Technology Major Project (D121100005012004)
精神分裂症(schizophrenia)是一种常见的精神疾病,在中国终身患病率大概为6.55‰.研究精神分裂症的语言认知,对精神分裂症的诊断和治疗具有重要的理论和应用价值.本文从行为和神经[事件相关电位(event-related potentials,ERP)、功能磁共振成像(functional magnetic resonance imaging,fMRI)、近红外光学成像(functional near-Infrared spectroscopy,fNIRS)]两个层面简述了国内外精神分裂症语言认知的研究进展.目前西方国家对精神分裂症的语言认知研究较多,结果也很丰富,初步形成了语言损伤的理论,而且发现幻听与语言加工相关脑区(wernicke区)有密切关系.精神分裂症的汉语认知研究起步较晚,各方面还不够深入和完善.作者提出应该大力加强对中国精神分裂症的语言认知研究,不仅可以更加清楚中国精神分裂症患者的语言特点,更重要的是可以为中国精神分裂症患者的诊断和探索发病机制提供新的科学依据.
Schizophrenia is a common mental disorder, the incidence of it in the whole life of Chinese is about 6.55‰. Exploring the language cognition is of great assistance in the diagnosis and therapy in schizophrenia. In this paper, the authors reviewed the advances of schizophrenia studies at behavioral and neural levels (event-related potentials (ERP),functional magnetic resonance imaging (fMRI) and functional near-infrared spectroscopy (fNIRS)). There were a battery of researches about schizophrenia in west countries using alphabetic language as their mother tongue, several theories about language impairment have been created. Particularly, the strong correlation between auditory hallucination and language processing related brain regions (Wernicke's area) was identified by many studies. However, the studies about Chinese schizophrenia are relatively rare since it started relatively later. The authors pointed out that it was greatly necessary to strengthen the researches of Chinese schizophrenia, not only for understanding the characteristics of language cognition of this disorder, but also for providing new scientific basis of diagnosis and therapy in the Chinese schizophrenia.
王久菊,王鹏飞,权文香,田菊,刘津,董问天.精神分裂症的语言认知特点及其脑机制[J].生物化学与生物物理进展,2015,42(1):49-55
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