Response inhibition of hand and eye-movement is to suppress the inappropriate response in hand and eye. Comparing with the classical paradigms such as Go/Nogo or Stop-signal, response inhibition of eye movement can provide more indices, and can separate from the confusion of verbal or hand movement. Response inhibition of hand and eye-movement differ in some neurological and psychiatric disorders, and the different developmental stages. Fronto-basal ganglia circuit play a similar role in eye and hand inhibition, but IFG is only key for hand response inhibition, and FEF and SC are only key for eye response inhibition. The arguments focused on the neural mechanisms, related higher cognitive activity, and the different performance and tendency in neuropsychology and developmental psychology.