Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education,Cancer Research Institute,Central South University,Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education,Cancer Research Institute,Central South University,Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education,Cancer Research Institute,Central South University,Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education,Cancer Research Institute,Central South University,Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education,Cancer Research Institute,Central South University,Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education,Cancer Research Institute,Central South University,Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education,Cancer Research Institute,Central South University,Hunan Key Laboratory of Nonresolving Inflammation and Cancer,Disease Genome Research Center,The Third Xiangya Hospital,Central South University,Hunan Provincial Tumor Hospital and The Affiliated Tumor Hospital of Xiangya Medical School,Central South University,Hunan Provincial Tumor Hospital and The Affiliated Tumor Hospital of Xiangya Medical School,Central South University,Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education,Cancer Research Institute,Central South University,Key Laboratory of Carcinogenesis of Ministry of Health and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education,Cancer Research Institute,Central South University;China;Hunan Key Laboratory of Nonresolving Inflammation and Cancer,Disease Genome Research Center,The Third Xiangya Hospital,Central South University;China;Hunan Provincial Tumor Hospital and The Affiliated Tumor Hospital of Xiangya Medical School,Central South University;China

This work was supported by grants from The National College Students' Innovation and Entrepreneurship Training Program of China (201310533063), The Students' Innovation and Entrepreneurship Training Program of Central South University (CY14283, CY14284) , The Free Exploration Program of Central South University (2282014bks197), and The Natural Science Foundation of Hunan Province (14JJ1010, 2015JJ1022)