蛋白酶3及其与疾病的关系研究进展

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蛋白酶3及其与疾病的关系研究进展
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作者单位:广东省医学分子诊断重点实验室; 广东医学院寄生虫学和临床寄生虫检验学教研室,广东医学院寄生虫学和临床寄生虫检验学教研室,广东省医学分子诊断重点实验室; 广东医学院寄生虫学和临床寄生虫检验学教研室
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基金项目:国家自然科学基金(81171599)，广东省高等学校科技创新项目(2013KJCX0087)和广东医学院科技创新团队项目(STIF201107)资助

Research Advances on Proteinase 3 and Its Relationship With Diseases

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Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics; Department of Parasitology and Clinical Parasitology, Guangdong Medical College,Department of Parasitology and Clinical Parasitology, Guangdong Medical College,Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics; Department of Parasitology and Clinical Parasitology, Guangdong Medical College

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This work was supported by grants from The National Natural Science Foundation of China (81171599), The Project of Department of Education of Guangdong Province (2013KJCX0087) and Science & Technology Innovation Fund of Guangdong Medical College (STIF201107)

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蛋白酶3(proteinase 3，PR3)是中性粒细胞分泌的主要丝氨酸蛋白酶之一，其生物学功能广泛，不仅能降解多种组织蛋白，还可通过加工细胞因子、受体等调控炎症反应，与慢性炎症性疾病如血管炎性肉芽肿病、慢性阻塞性肺疾病、肺囊肿性纤维症的发生发展密切相关，可能作为疾病防治靶点．本文主要综述了PR3的生物学功能及其在疾病中的可能作用机制，期望为相关疾病的防治提供新的思路．

Abstract:

Proteinase 3 is one of the major serine proteases secreted by neutrophils with multiple biological functions. It can degradate tissue proteins, process cytokines and receptors, thus contributing to the regulation of inflammatory and immune responses, and play important roles in the occurrence and development of chronic inflammatory diseases, such as granulomatosis with polyangiitis, chronic obstructive pulmonary diseases and pulmonoary fibrosis. In this reviews, we describle the biological functions of PR3 and its roles in human diseases, which might provide a new insight for the prevention and treatment of human diseases.

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刘广花,邓莉,彭礼飞.蛋白酶3及其与疾病的关系研究进展[J].生物化学与生物物理进展,2015,42(3):244-253

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收稿日期:2014-09-13
最后修改日期:2015-01-07
接受日期:2015-01-13
在线发布日期: 2015-03-24
出版日期: 2015-03-20

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