The incidence rate of epithelial ovarian cancers ranks third among female reproductive system cancers, and its mortality rate stands first among the list of gynecologic tumors. The standard mode of treatment is cytoreductive surgery (debulking) plus the administration of platinum-based chemotherapy drugs. About 70% of advanced patients who receive standard treatments can achieve clinical remission. However, a certain percentage of patients with clinical remission will still experience tumor recurrence, metastasis, and drug resistance. this study focuses on the occurrence process of EMT in SKOV3 cells, which is mediated by RAC1 activation, as well as the relationship between the process of cell sensitivity and cisplatin (CDDP), and the ability of invasion and metastasis.