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高通量RNA甲基化测序数据处理与分析研究进展
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西北工业大学自动化学院,西北工业大学自动化学院,西交利物浦大学生物科学系,中国科学院生物物理所

基金项目:

国家自然科学基金资助项目(91430111, 61473232, 61401370, 61170134)


Recent Progress and Challenges in High Throughput RNA Methylation Sequencing Data Analysis
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Affiliation:

Key Laboratory of Information Fusion of Ministry of Education,School of Automation,Northwestern Polytechnical University,Xi’an,Key Laboratory of Information Fusion of Ministry of Education,School of Automation,Northwestern Polytechnical University,Xi’an,Department of Biological Sciences, Xi'an Jiaotong-Liverpool University,Institute of Biophysics, Chinese Academy of Sciences

Fund Project:

This work was supported by a grant from The National Natural Science Foundation of China(91430111, 61473232, 61401370, 61170134)

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    摘要:

    随着高通量测序技术快速发展，MeRIP-seq (methylated RNA immunoprecipitation sequencing) 测序技术开启了RNA表观遗传学研究新局面，能够在全基因组范围内描述RNA甲基化．从MeRIP-seq高通量数据中挖掘RNA甲基化模式，有助于揭示mRNA甲基化在调控基因表达、剪切等方面所发挥的潜在功能，有效指导癌症的干预治疗．本文从MeRIP-seq测序原理出发，较全面地综述MeRIP-seq数据处理和分析方法研究现状，并对其所面临的计算问题进行讨论和展望．

    Abstract:

    With the rapid development of high-throughput sequencing technologies, the emerging of methylated RNA immunoprecipitation sequencing (MeRIP-seq) technology makes it possible to detect RNA epigenetic modifications in a large scale, which allows transcriptome-wide profiling of RNA methylation. Mining the patterns of global mRNA methylation from these MeRIP-seq data can help reveal the potential functional roles of these mRNA methylations in regulating gene expression, splicing, RNA editing and RNA stability, effectively guiding the therapeutic intervention of cancer. Here, the principle of MeRIP-seq sequencing was first introduced. Then, the recent progress of the processing and analysis of MeRIP-seq data were comprehensively discussed. In the end, the computational problems and challenges faced in the process of MeRIP-seq data processing were also summarized.

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刘恋,张绍武,孟佳,陈润生.高通量RNA甲基化测序数据处理与分析研究进展[J].生物化学与生物物理进展,2015,42(10):891-899

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历史
  • 收稿日期:2015-03-23
  • 最后修改日期:2015-06-22
  • 接受日期:2015-07-01
  • 在线发布日期: 2015-10-20
  • 出版日期: 2015-10-20
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