中国科学院动物研究所,运城学院,中国科学院动物研究所,中国科学院动物研究所,中国科学院动物研究所
Institute of Zoology, Chinese Academy of Sciences,yuncheng university,Institute of Zoology, Chinese Academy of Sciences,Institute of Zoology, Chinese Academy of Sciences,Institute of Zoology, Chinese Academy of Sciences
以秀丽隐杆线虫为材料发现,prg-1基因突变不仅影响piRNA的表达,还影响部分miRNA的表达,同时还发现ncRNA-like型小RNA,对ncRNA-like序列比较,认为ncRNA-like与piRNA或miRNA序列极为相似;对ncRNA-like与miRNA或piRNA的基因座比较,发现ncRNA-like与miRNA或piRNA基因座完全相同.推测这些ncRNA-like型小RNA可能与miRNA或piRNA有着相同的RNA前体来源.
In Caenorhabditis elegans, the expression of all piRNAs, small of miRNAs were influenced by the mutation of prg-1. Especially, some ncRNA-like, a kinds of small RNA, were found in C. elegans. The ncRNA-like had the similar sequence with piRNAs or miRNAs. The results of the analysis in the gene sites between the ncRNA-like and piRNAs or between ncRNA-like and miRNAs, showed that ncRNA-like had the same gene sites with piRNAs or miRNAs. All of these showed that the ncRNA-like were a kind of small RNA and may be processed from the RNA precursor same to piRNAs or miRNAs.
黄大卫,崔东亚,王佳佳,何顺民,张鹏.线虫prg-1基因对小RNA表达的影响[J].生物化学与生物物理进展,2016,43(3):265-270
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